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4 Benefits Of Creatine Supplementation

As a health and performance supplement, creatine has been used by athletes and fitness enthusiasts for decades. In fact, it is one of the most heavily researched supplements on the market. A quick look at will give you dozens of articles written on the benefits or potential benefits of supplementing your diet regimen with creatine, and those barely scratch the surface on the body of work surrounding this substance.

Creatine is a derivative of the amino acids arginine, glycine, and methionine. We naturally produce about 1-2g/day in our kidneys, liver, and pancreas. Creatine can also be absorbed by consuming red meats, salmon, and supplementation (creatine monohydrate). About 90-95% of the creatine we absorb goes to our muscles. Creatine is broken down into creatinine and excreted through our urine at a rate of about 2g/day, depending upon consumption and activity levels.

Why supplement with creatine? 

Well, do you care about your exercise performance? Are you looking to support or build lean muscle? Are you concerned with improving your brain function or defending yourself against neurological diseases as you age?

Daily supplementation with creatine can help with all of these areas, which is why it’s worthy of your attention. Let’s take a look.

1. Improvement In Intense Exercise Performance

Our muscles rely on a substance called adenosine triphosphate (ATP), which is a byproduct of our phosphogenic energy system, to effectively perform short, fast bursts of energy, such as sprinting, ballistic movements, Olympic lifting, a heavy squat, etc. Creatine’s direct effect on the production of ATP in our muscles can help create more potential available ATP, in turn, improving the performance of short, intense exercises and efforts. 

Endurance athletes likely won’t see quite the same benefits, due to their sports’ reliance on the aerobic energy system. However, creatine supplementation has a “cell volumizing effect”, which pulls more water into the muscle cells. Over time, and with some resistance training, this could result in more muscle glycogen storage and protein synthesis, thus, aiding in muscle endurance and reducing protein breakdown. 

2. Supports Muscular Size and Strength

One of creatine’s primary functions as a supplement is to increase muscle size and strength. In fact, it has shown to be the most effective supplement on the market for such a task. The initial gains are seen via the additional water being pulled into the muscle cells. Over time, prolonged supplementation activates specific channels that aid in muscle tissue growth, strength, and performance. 

In this study, 25 male subjects (7 control, 8 creatine group, and 10 placebo group) were subjected to a 42-day strength training program. At the end of the program, the control and placebo groups did not see any change in their lean, skeletal muscle mass. However, the creatine group saw gains of 2.0kg (4.4lbs) in mass.

There is also growing evidence that creatine supplementation can aid in raising levels of insulin-like growth factor 1 (IGF-1). This becomes increasingly more important as we age and start losing muscle mass. IGF-1 aids in the production of lean tissues, so being able to keep levels up as we age might help us retain lean muscle mass, which is directly related to long-term health and vitality.

3. Improvement In Brain Function

More recent studies on creatine have been exploring its positive effects on brain function and overall neurological health. Your muscles aren’t the only body parts that rely on ATP. Your brain relies on it, as well, when completing complex tasks. The brain produces ATP, so supplementation can aid in that production. Creatine can also assist in increasing dopamine levels and enhancing mitochondrial function.

These benefits are most profound in older individuals. The above benefits can help older adults maintain or improve memory recall. This boost in brain function might also help in mitigating or treating chronic neurological diseases. It is unclear whether younger adults can enjoy the same benefits. More research is needed.

4. Possible Defense Against Neurological Disease

More recent, cutting-edge research on creatine use has been its possible therapeutic use for degenerative neurological diseases. It is known that depleted phosphocreatine levels in the brain can contribute to neurological disease. However, it is still unclear whether or not supplementing with creatine can definitively slow the progression of or treat these diseases. 

For instance, in this animal study, a combination of coenzyme Q10 and creatine was administered to mice with Huntington’s Disease and rats with Parkinson’s Disease. The study proved promising in the combination of the two supplements to provide “neuroprotective” effects on both populations of animals. 

Another animal study involving mice with Amylotrophic Lateral Sclerosis (ALS) showed promising neuroprotective effects, as well. Supplementation of creatine improved the animals’ motor functions and slowed muscle loss, thus increasing the survival rate of the test subjects. 

Researchers are also looking at creatine supplementation to possibly help with Alzheimer’s, spinal cord injuries, epilepsy, muscular dystrophy, and strokes. However, there needs to be more tests on actual humans to see if any of these possible benefits can carry over.


Creatine has many positive uses for athletes and fitness enthusiasts, and can possibly be a therapeutic tool for treating serious, degenerative neurological diseases. Aside from protein, creatine is probably the most studied and effective supplement you can buy, and it’s cheap! You can easily find deals on Amazon for 400 servings of creatine monohydrate (most effective form) for less than $40. That’s a 400 day supply for less than your average 2lb tub of protein.

Taking one serving of creatine daily, which for most manufacturers is around 5g is perfectly safe. In the old days, there used to be a “loading phase” where you would take 20g/day for the first week, then transition to a “maintenance phase” of 5g/day. You can still do that, but it isn’t necessary. It also isn’t necessary to cycle on and off creatine, since it isn’t a hormone. It doesn’t taste like anything, so mixing it in a beverage or protein shake makes ingesting it easy.

Next time you want to try adding a new supplement to your diet, give it a try. It’s cheap, effective, and safe. 

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